Information about sperm DNA integrity may help in the clinical diagnosis, management and treatment of male infertility and may be of prognostic value in assessing outcome of assisted conception treatment 15, In general, samples with low DNA fragmentation present higher probability of successful pregnancy occurring naturally 6. Value of the sperm deoxyribonucleic acid fragmentation level, as measured by the sperm chromatin dispersion test, in the outcome of in vitro fertilization and intracytoplasmic sperm injection. Other factors include defects in sperm chromatin packaging and DNA repair mechanisms as well as abnormalities in the regulation of programmed cell death abortive apoptosis which is vital for regulating sperm production The article by Ashok Agarwal et al. Fertility, after all, is a joint effort of two people—man and woman.
Non-genetic contributions of the sperm nucleus to embryonic development.
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Indian J Urol ; Author information Article notes Copyright and License information Disclaimer. Spermatozoa bound to solid state hyaluronic acid show chro-matin structure with high DNA chain integrity: MAC wrote the paper, revised the paper and analysed the data. GL carried out the laboratory experiments, analysed the data, interpreted the results and wrote the paper. By continuing to use this site, you are agreeing to their use.